Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass
نویسندگان
چکیده
منابع مشابه
Effect of ACE inhibition on glomerular permselectivity and tubular albumin concentration in the renal ablation model.
Despite the central role of tubular plasma proteins that characterize progressive kidney diseases, protein concentrations along the nephron in pathological conditions have not been quantified so far. We combined experimental techniques and theoretical analysis to estimate glomerular and tubular levels of albumin in the experimental model of 5/6 nephrectomy (Nx) in the rat, with or without angio...
متن کاملCALL FOR PAPERS Renal Hemodynamics Effect of ACE inhibition on glomerular permselectivity and tubular albumin concentration in the renal ablation model
Sangalli F, Carrara F, Gaspari F, Corna D, Zoja C, Botti L, Remuzzi G, Remuzzi A. Effect of ACE inhibition on glomerular permselectivity and tubular albumin concentration in the renal ablation model. Am J Physiol Renal Physiol 300: F1291–F1300, 2011. First published March 30, 2011; doi:10.1152/ajprenal.00656.2010.— Despite the central role of tubular plasma proteins that characterize progressiv...
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Rat kidney endothelial cell morphology was examined after introducing iron colloid particles of positive or negative charge to investigate the relationship between the electric charge and permeation through the glomerular capillary. The kidneys were first perfused with Hanks’ solution through the renal arteries and then with iron colloid particles of positive or negative charge. The iron colloi...
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Changes in glomerular permselectivity are the physiological basis for proteinuria, which typically accompanies chronic kidney disease. Traditionally changes in the sizerestrictive properties of the glomerular barrier have been quantified by measuring the fractional clearance ( ) of exogenous infused dextrans and interpreting the results using the hindered transport theory for uncharged, solid s...
متن کاملFunctional and hemodynamic adaptation to progressive renal ablation.
Removal of renal tissue stimulates functional and anatomical adaptation in the remaining renal parenchyma. Since recent studies have demonstrated no apparent limitation in compensatory growth following progressive surgical ablation, experiments were performed to determine the changes in glomerular filtration rate and renal blood flow. After removal of 50% of the renal mass mean nephron glomerul...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1982
ISSN: 0085-2538
DOI: 10.1038/ki.1982.143